Structure of PDB 5ven Chain B

Receptor sequence
>5venB (length=373) Species: 10090 (Mus musculus) [Search protein sequence]
QKVLVVSFDGFRWDYLYKVPTPHFHYIMKNGVHVNQVTNVFITKTYPNHY
TLVTGLFAENHGIVANDMFDPILNKSFSLEHMDIYDSKFWEEATPIWITN
QRAGHASGAAMWPGADVKIHDSFPTYYLPYNESVSFEDRVAKIIEWFTAK
DPINLGFLYWEEPDDTGHDVGPDSPLMGSVISDVDHKLGYLIKMLKRAKL
WNNVNLIVTSDHGMTQCSKQRVIELDRYLDKEHYTLIDHSPVAAILPKEG
KFDEVYDALAGAHPNLTVYKKEEIPERWHYKHNDRVQPIVAVADEGWYIL
QNKSDDFLLGNHGYDNALAEMHPIFLAHGPAFRKNFTKEAMNSTDLYSLL
CHLLNLTALPHNGSFWNVQDLLS
3D structure
PDB5ven A key tyrosine substitution restricts nucleotide hydrolysis by the ectoenzyme NPP5.
ChainB
Resolution1.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUC B N101 K102 S103 N74 K75 S76
BS02 ZN B D191 H195 H339 D164 H168 H312
BS03 ZN B D36 T72 D238 H239 D9 T45 D211 H212
BS04 ZN B E159 D192 E132 D165
Gene Ontology
Molecular Function
GO:0000210 NAD+ diphosphatase activity
GO:0004551 dinucleotide phosphatase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0007154 cell communication
GO:0009166 nucleotide catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5ven, PDBe:5ven, PDBj:5ven
PDBsum5ven
PubMed28898552
UniProtQ9EQG7|ENPP5_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (Gene Name=Enpp5)

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