Structure of PDB 5vem Chain B

Receptor sequence
>5vemB (length=383) Species: 9606 (Homo sapiens) [Search protein sequence]
HHHHKLPDQQKVLLVSFDGFRWDYLYKVPTPHFHYIMKYGVHVKQVTNVF
ITKTYPNHYTLVTGLFAENHGIVANDMFDPIRNKSFSLDHMNIYDSKFWE
EATPIWITNQRAGHTSGAAMWPGTDVKIHKRFPTHYMPYNESVSFEDRVA
KIIEWFTSKEPINLGLLYWEDPDDMGHHLGPDSPLMGPVISDIDKKLGYL
IQMLKKAKLWNTLNLIITSDHGMTQCSEERLIELDQYLDKDHYTLIDQSP
VAAILPKEGKFDEVYEALTHAHPNLTVYKKEDVPERWHYKYNSRIQPIIA
VADEGWHILQNKSDDFLLGNHGYDNALADMHPIFLAHGPAFRKNFSKEAM
NSTDLYPLLCHLLNITAMPHNGSFWNVQDLLNS
3D structure
PDB5vem A key tyrosine substitution restricts nucleotide hydrolysis by the ectoenzyme NPP5.
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B D36 T72 D238 H239 D18 T54 D220 H221
BS02 ZN B D191 H195 H339 D173 H177 H321
BS03 ZN B D192 H196 D174 H178
Gene Ontology
Molecular Function
GO:0000210 NAD+ diphosphatase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0007154 cell communication
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5vem, PDBe:5vem, PDBj:5vem
PDBsum5vem
PubMed28898552
UniProtQ9UJA9|ENPP5_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (Gene Name=ENPP5)

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