Structure of PDB 5vdr Chain B

Receptor sequence
>5vdrB (length=353) Species: 9606 (Homo sapiens) [Search protein sequence]
MGASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLL
NTGAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEG
EILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISV
DITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGN
GFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLE
QLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCV
TYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPV
FDE
3D structure
PDB5vdr The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
ChainB
Resolution3.042 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H390 C397 C404 H222 C229 C236
BS02 9B7 B R423 F424 Q507 Y510 R255 F256 Q339 Y342
BS03 9B7 B M229 P306 K362 R376 S378 S380 S434 Y436 M61 P138 K194 R208 S210 S212 S266 Y268
External links
PDB RCSB:5vdr, PDBe:5vdr, PDBj:5vdr
PDBsum5vdr
PubMed28940468
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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