Structure of PDB 5v8o Chain B

Receptor sequence
>5v8oB (length=349) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
TGSKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQF
LEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEK
ISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHQE
ETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKE
RFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFL
QCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDE
3D structure
PDB5v8o Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.
ChainB
Resolution3.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H390 C397 C404 H218 C225 C232
BS02 8ZM B A247 R376 Y436 N482 F488 L490 A82 R204 Y264 N310 F316 L318 BindingDB: Kd=170000nM,IC50=78000nM
BS03 8ZM B K506 Q507 Y510 K334 Q335 Y338 BindingDB: Kd=170000nM,IC50=78000nM
External links
PDB RCSB:5v8o, PDBe:5v8o, PDBj:5v8o
PDBsum5v8o
PubMed28934246
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

[Back to BioLiP]