Structure of PDB 5v54 Chain B

Receptor sequence
>5v54B (length=383) Species: 9606 (Homo sapiens) [Search protein sequence]
DYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANY
LIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTAS
IWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFF
WRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEAR
SRIADLEDRWRTLEDNLRVIERAANAAEVREALTRMRAAAEDAQRATPPS
PASPEMEDFRHGFDILVGQIDDALRLADEGRVAEAQAAAEELRTTRNAYI
QKYLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICFHLAIFDFFT
WLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKC
3D structure
PDB5v54 A common antagonistic mechanism for class A GPCRs revealed by the structure of the human 5-HT1B serotonin receptor bound to an antagonist
ChainB
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 89F B D129 I130 C133 T134 I137 A216 W327 F330 F331 Y359 D93 I94 C97 T98 I101 A180 W327 F330 F331 Y354 BindingDB: Ki=16.98nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:5v54, PDBe:5v54, PDBj:5v54
PDBsum5v54
PubMed
UniProtP28222|5HT1B_HUMAN 5-hydroxytryptamine receptor 1B (Gene Name=HTR1B)

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