Structure of PDB 5v19 Chain B

Receptor sequence
>5v19B (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
LLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERQPLHE
EIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLK
DNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFG
TSKRCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPP
FYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACAN
DLLVDEFLKV
3D structure
PDB5v19 Structure-based drug design of novel ASK1 inhibitors using an integrated lead optimization strategy.
ChainB
Resolution3.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D803 K805 D807 N808 D822 T842
Catalytic site (residue number reindexed from 1) D129 K131 D133 N134 D148 T162
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8V4 B V738 M754 Q756 V757 L810 V64 M80 Q82 V83 L136
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5v19, PDBe:5v19, PDBj:5v19
PDBsum5v19
PubMed28291695
UniProtQ99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (Gene Name=MAP3K5)

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