Structure of PDB 5uw6 Chain B

Receptor sequence
>5uw6B (length=706) Species: 39387 (Gypsophila vaccaria) [Search protein sequence]
ATSGFSKPLHYPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVDN
QEKLANSVLEECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGLQ
AQNVFQMQDDLDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHSG
LTEWVTIKILKTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPPAVNQ
EARYHFLGTDQSEDILLWRDLENPAHHLKCQITDDGKYFLLYILDGCDDA
NKVYCLDLTKLPNGLESSAPFMKLIDSFDASYTAIANDGSVFTFQTNKDA
PRKKLVRVDLNNPSVWTDLVPESKKDLLESAHAVNENQLILRYLSDVKHV
LEIRDLESGALQHRLPIDIGSVDGITARRRDSVVFFKFTSILTPGIVYQC
DLKNDPTQLKIFRESVVPDFDRSEFEVKQVFVPSKDGTKIPIFIAARKGI
SLDGSHPCEMHGYGGFGINMMPTFSASRIVFLKHLGGVFCLANIRGGGEY
GEEWHKAGFRDKKQNVFDDFISAAEYLISSGYTKARRVAIEGGSNGGLLV
AACINQRPDLFGCAEANCGVMDMLRFHKFTLGYLWTGDYGCSDKEEEFKW
LIKYSPIHNVRRPWEQPGNEETQYPATMILTADHDDRVVPLHSFKLLATM
QHVLCTSLEDSPQKNPIIARIQRKAAHYGRATMTQIAEVADRYGFMAKAL
EAPWID
3D structure
PDB5uw6 Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants.
ChainB
Resolution3.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H695
Catalytic site (residue number reindexed from 1) H677
Enzyme Commision number 3.4.21.-
3.4.21.26: prolyl oligopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B R81 F95 A102 N104 F492 S493 A494 S495 T700 I704 R80 F94 A101 N103 F474 S475 A476 S477 T682 I686
BS02 ZPR B H239 C259 Y481 F484 S562 N563 W603 R655 V656 H227 C247 Y463 F466 S544 N545 W585 R637 V638
BS03 CA B E64 D67 E63 D66
BS04 CA B A717 E719 A699 E701
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
GO:0070012 oligopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uw6, PDBe:5uw6, PDBj:5uw6
PDBsum5uw6
PubMed28584123
UniProtR4P353

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