Structure of PDB 5uvw Chain B

Receptor sequence
>5uvwB (length=106) Species: 9606 (Homo sapiens) [Search protein sequence]
TNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGT
IKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQ
KINELP
3D structure
PDB5uvw BRD4_Bromodomain1-A1376855
ChainB
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8NG B W81 P82 Q85 V87 K91 L92 L94 N140 I146 W22 P23 Q26 V28 K32 L33 L35 N81 I87 BindingDB: IC50=20nM,Ki=1.5nM,Kd=<10.0nM,EC50=20nM
External links
PDB RCSB:5uvw, PDBe:5uvw, PDBj:5uvw
PDBsum5uvw
PubMed
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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