Structure of PDB 5urm Chain B

Receptor sequence

>5urmB (length=1691) Species: 9606 (Homo sapiens)

APRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPALKPK
PFGSLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTG
AGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFG
KRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYT
QLVRLIILDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLP
NYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNE
IVYEKIMEHQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREEVLRTE
AEQCKNLELKDLLPFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAW
GVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEG
ILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDAV
NWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKN
NLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRV
FSLSSEFKNITVREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFI
SQLKLEGFALMADMVYVTQSAGRLMRAIFEIVLNRGWAQLTDKTLNLCKM
IDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDLNHNEIGELIRM
PKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHGS
SEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPLPPQYF
IRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAF
ESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRM
LLQSSEGRCVYITPMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLK
LLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIGGENGPVL
EVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLGCSATSTFNFHPN
VRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITKHSPKKPVIVFVPSRK
QTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGV
GYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQ
YYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKF
LYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVDYLTWTFLYRRMTQN
PNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEMDVAPLNLGM
IAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNL
LRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILS
KAIRLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDSYLKQLPHFT
SVFDIMEMEDEERNLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGP
VVVLVQLEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSNSLISIKRLTL
QQKAKVKLDFVAPATGAHNYTLYFMSDAYMGCDQEYKFSVD

3D structure

• PDB: 5urm Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.
• Chain: B
• Resolution: 2.8 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	8LV	B	R545 T589 E591 K592 I595	R139 T183 E185 K186 I189

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0005524 ATP binding

External links

• PDB: RCSB:5urm, PDBe:5urm, PDBj:5urm
• PDBsum: 5urm
• PubMed: 28586220
• UniProt: O75643|U520_HUMAN U5 small nuclear ribonucleoprotein 200 kDa helicase (Gene Name=SNRNP200)