Structure of PDB 5uqu Chain B

Receptor sequence
>5uquB (length=436) Species: 451804 (Aspergillus fumigatus A1163) [Search protein sequence]
TAEPDLKTALKAVIPAKRELFKQVKERSDEVIGEVKVANVIGGMRGLKSM
LWEGSVLDPEEGIRFHGKTIKDCQKELPKGTSGTEMLPEAMFWLLLTGQV
PSTNQVRAFSRELAEQSHLPQHILDLIKSFPRSMHPMTQLSIAVAALNTE
SKFAKAYEKGLSKADYWEPTFDDSISLLAKIPRVAALVFRPDEVDQVGTQ
ALDASQDWSYNFAELLGKGGKENQDFHDLLRLYLALHGDHEGGNVSAHAT
HLVGSALSDPFLSYSAGLLGLAGPLHGLAAQEVLRWILAMQDKIGTKFTD
DDVRNYLWDTLKSGRVVPGYGHAVLRKPDPRFQALMDFAATRPDVLANPV
FQLVKKNSEIAPAVLTEHGKTKNPHPNVDAASGVLFYHYGFQQPLYYTVT
FGVSRALGPLVQLIWDRALGLPIERPKSINLLGLKK
3D structure
PDB5uqu Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase.
ChainB
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S275 H305 H351 R360 D408
Catalytic site (residue number reindexed from 1) S246 H276 H322 R331 D379
Enzyme Commision number 2.3.3.16: citrate synthase (unknown stereospecificity).
2.3.3.5: 2-methylcitrate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA B R74 L304 A308 V345 V346 G348 Y349 G350 H351 A352 K399 T400 K401 N406 R45 L275 A279 V316 V317 G319 Y320 G321 H322 A323 K370 T371 K372 N377
Gene Ontology
Molecular Function
GO:0004108 citrate (Si)-synthase activity
GO:0016740 transferase activity
GO:0036440 citrate synthase activity
GO:0042802 identical protein binding
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer
GO:0050440 2-methylcitrate synthase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0019629 propionate catabolic process, 2-methylcitrate cycle
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uqu, PDBe:5uqu, PDBj:5uqu
PDBsum5uqu
PubMed31141475
UniProtB0YD89|PRPC_ASPFC 2-methylcitrate synthase, mitochondrial (Gene Name=mcsA)

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