Structure of PDB 5uqr Chain B

Receptor sequence
>5uqrB (length=435) Species: 746128 (Aspergillus fumigatus) [Search protein sequence]
AEPDLKTALKAVIPAKRELFKQVKERSDEVIGEVKVANVIGGMRGLKSML
WEGSVLDPEEGIRFHGKTIKDCQKELPKGTSGTEMLPEAMFWLLLTGQVP
STNQVRAFSRELAEQSHLPQHILDLIKSFPRSMHPMTQLSIAVAALNTES
KFAKAYEKGLSKADYWEPTFDDSISLLAKIPRVAALVFRPDEVDQVGTQA
LDASQDWSYNFAELLGKGGKENQDFHDLLRLYLALHGDHEGGNVSAHATH
LVGSALSDPFLSYSAGLLGLAGPLHGLAAQEVLRWILAMQDKIGTKFTDD
DVRNYLWDTLKSGRVVPGYGHGVLRKPDPRFQALMDFAATRPDVLANPVF
QLVKKNSEIAPAVLTEHGKTKNPHPNVDAASGVLFYHYGFQQPLYYTVTF
GVSRALGPLVQLIWDRALGLPIERPKSINLLGLKK
3D structure
PDB5uqr Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase.
ChainB
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S275 H305 H351 R360 D408
Catalytic site (residue number reindexed from 1) S245 H275 H321 R330 D378
Enzyme Commision number 2.3.3.16: citrate synthase (unknown stereospecificity).
2.3.3.5: 2-methylcitrate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OAA B H269 N273 H305 H351 R360 R434 H239 N243 H275 H321 R330 R404
BS02 8JD B R74 L304 A308 V345 V346 G348 Y349 G350 H351 G352 K399 T400 N406 D408 F430 R44 L274 A278 V315 V316 G318 Y319 G320 H321 G322 K369 T370 N376 D378 F400
Gene Ontology
Molecular Function
GO:0004108 citrate (Si)-synthase activity
GO:0016746 acyltransferase activity
GO:0036440 citrate synthase activity
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer
GO:0050440 2-methylcitrate synthase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0019543 propionate catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uqr, PDBe:5uqr, PDBj:5uqr
PDBsum5uqr
PubMed31141475
UniProtQ50I20|PRPC_ASPFM 2-methylcitrate synthase, mitochondrial (Gene Name=mcsA)

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