Structure of PDB 5uow Chain B

Receptor sequence
>5uowB (length=795) Species: 8355 (Xenopus laevis) [Search protein sequence]
FPVLNIAVILGRTRYITERDIRSLWTRDMSLDFDVNVVTLLVQQTDPKSI
ITHVCDLMSGTKIHGVVFGDDTDQEAIAQILDFVSSQTFIPILGIHGGSS
MIMADKDEMSTFFQFGASIKQQATVMLNIMEEYDWHVFSVITSNFPGYRD
FISFIKTTVDNSFVGWEVQNYITLDTSYTDAQTLTQLKKIHSSVILLYCS
KDEATYIFEEARSLGLMGYGFVWIVPSLVTGNTDIIPYEFPSGLVSVSYD
DWDYGIEARVRDGLGIITTAASAMLEKHSVIPEAKTSCYGQNERNDPPLH
TLHNFMINVTWDGKDLSFTEDGYQANPKLVVLLLNMEREWEKVGKWEAKS
LNMKYPVWPRIDSDHDDNHLSIVTLEEAPFVIVENIDYLTGTCVRNTVPC
RKYFRLANSTTEGTSVKKCCKGFCIDILKKLSKTVKFTYDLYLVTNGKHG
KKIKNVWNGMIGEVVYKRAVMAVGSLTINEERSVAVDFSVPFVETGISVM
VSRSAGTVSPSAFLEPFSASVWVMMFVMLLLVSAMAVFIFEYFSPVHGPS
FTIGKAVWLLWGLVFNNSLPVQNPKGTTSKIIVSIWAFFAVIFLASYTAN
LAAFMIQRRFVDQVTGLSDNKFQRPHDYSPPFRFGTVPQGSTERNIRNNY
PDMHQYMVKFHQKGVQDALVSLKTGKLDAFIYDAAVLNYMAGRDEGCKLV
TIGSGYIFATTGYGIALQKGSRWKRPIDLALLQFVGDGEMEELEKLWLTG
ICHTEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFVWEHLFYK
3D structure
PDB5uow Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.
ChainB
Resolution4.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU B H473 T501 G676 S677 T678 D719 H449 T477 G640 S641 T642 D683
BS02 BMK B L630 T634 L594 T598
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uow, PDBe:5uow, PDBj:5uow
PDBsum5uow
PubMed28232581
UniProtB7ZSK1|NMDE1_XENLA Glutamate receptor ionotropic, NMDA 2A (Gene Name=grin2a)

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