Structure of PDB 5unp Chain B

Receptor sequence
>5unpB (length=347) Species: 9606 (Homo sapiens) [Search protein sequence]
SRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRG
GARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYH
GHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKL
THTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHE
HHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDN
REHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCK
PLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLR
3D structure
PDB5unp A novel CLK inhibitor exhibits anti-tumor efficacies via modulating pre-mRNA splicing and targeting a MYC-dependent vulnerability
ChainB
Resolution2.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8FY B L169 G170 E171 V177 K193 F243 L246 G247 L297 V326 D327 L33 G34 E35 V41 K57 F107 L110 G111 L161 V190 D191
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5unp, PDBe:5unp, PDBj:5unp
PDBsum5unp
PubMed
UniProtP49760|CLK2_HUMAN Dual specificity protein kinase CLK2 (Gene Name=CLK2)

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