Structure of PDB 5und Chain B

Receptor sequence

>5undB (length=145) Species: 9606 (Homo sapiens)

EKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRH
MRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIA
RKSDLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNE

3D structure

• PDB: 5und Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA.
• Chain: B
• Resolution: 2.549 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	T391 Y392 K395 Y407 K423 K449 S450 R457	T44 Y45 K48 Y60 K76 K102 S103 R110
BS02	dna	B	Y358 E362 K365 R368 H369 R377 Y386 R389 K393 R396 K405 F416 Q418 K429 I446 A447 R448 D451 H455 Q459 R479	Y11 E15 K18 R21 H22 R30 Y39 R42 K46 R49 K58 F69 Q71 K82 I99 A100 R101 D104 H108 Q112 R132
BS03	ZN	B	C356 H369 H373	C9 H22 H26
BS04	ZN	B	C384 H397 H401	C37 H50 H54
BS05	ZN	B	C409 C412 H425 H430	C62 C65 H78 H83
BS06	ZN	B	C439 C442 H455 H460	C92 C95 H108 H113
BS07	ZN	B	C469 C472 H485 H489	C122 C125 H138 H142

External links

• PDB: RCSB:5und, PDBe:5und, PDBj:5und
• PDBsum: 5und
• PubMed: 28529057
• UniProt: P49711|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF)