Structure of PDB 5un8 Chain B

Receptor sequence
>5un8B (length=426) Species: 9606 (Homo sapiens) [Search protein sequence]
HFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWR
EMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKL
DQVSQFGCRSFALLFDNIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGE
PETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKE
IPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLK
GVLTNPNCEFEANYVAIHTLATWYKYSPQMALKLALTEWLQEFGVPHQYS
SVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVKIEEWRSRA
AKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWL
GCRSWAFRGGLAGEFQRLLPIDGAND
3D structure
PDB5un8 Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode.
ChainB
Resolution2.13 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.169: protein O-GlcNAcase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y69 N175 I176 D177 Y219 F223 V254 Y11 N117 I118 D119 Y161 F165 V196
BS02 peptide B W645 K648 M653 W384 K387 M392
External links
PDB RCSB:5un8, PDBe:5un8, PDBj:5un8
PDBsum5un8
PubMed28319083
UniProtO60502|OGA_HUMAN Protein O-GlcNAcase (Gene Name=OGA)

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