Structure of PDB 5umb Chain B

Receptor sequence
>5umbB (length=378) Species: 5843 (Plasmodium falciparum NF54) [Search protein sequence]
EGPVIGIDLGTTYSCVGVFKNGRVEILNNELGNRITPSYVSFVDGERKVG
EAAKLEATLHPTQTVFDVKRLIGRKFDDQEVVKDRSLLPYEIVNNQGKPN
IKVQIKDKDTTFAPEQISAMVLEKMKEIAQSFLGKPVKNAVVTVPAYFND
AQRQATKDAGTIAGLNIVRIINEPTAAALAYGLDKKEETSILVYDLGGGT
FDVSILVIDNGVFEVYATAGNTHLGGEDFDQRVMDYFIKMFKKKNNIDLR
TDKRAIQKLRKEVEIAKRNLSVVHSTQIEIEDIVEGHNFSETLTRAKFEE
LNDDLFRETLEPVKKVLDDAKYEKSKIDEIVLVGGSTRIPKIQQIIKEFF
NGKEPNRGINPDEAVAYGAAIQAGIILG
3D structure
PDB5umb Repurposing drugs to target the malaria parasite unfolding protein response.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.10: non-chaperonin molecular chaperone ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B T38 Y39 G223 G224 E290 K293 R294 S297 G361 R364 T12 Y13 G197 G198 E264 K267 R268 S271 G335 R338
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0140662 ATP-dependent protein folding chaperone

View graph for
Molecular Function
External links
PDB RCSB:5umb, PDBe:5umb, PDBj:5umb
PDBsum5umb
PubMed29985421
UniProtQ05866|BIP_PLAFO Endoplasmic reticulum chaperone BIP (Gene Name=BIP)

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