Structure of PDB 5uhn Chain B

Receptor sequence
>5uhnB (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
PEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKM
LKDDATEKDLSDLVSEMEMMKMIGKHKNIIHLLGACTQDGPLYVIVAYAS
KGNLREYLRARRQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV
TENNVMKIADFGLARDIGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWE
IFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPS
QRPTFKQLVEDLDRILTLT
3D structure
PDB5uhn Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
ChainB
Resolution2.909 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D626 A628 R630 N631 D644 R664
Catalytic site (residue number reindexed from 1) D142 A144 R146 N147 D160 R169
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP B L487 G490 A491 F492 A515 Y566 A567 L633 D644 L19 G22 A23 F24 A47 Y98 A99 L149 D160
BS02 MG B R630 N631 D644 R146 N147 D160
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5uhn, PDBe:5uhn, PDBj:5uhn
PDBsum5uhn
PubMed28166054
UniProtP21802|FGFR2_HUMAN Fibroblast growth factor receptor 2 (Gene Name=FGFR2)

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