Structure of PDB 5ugx Chain B

Receptor sequence
>5ugxB (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
LPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVK
MLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYA
SKGNLREYLRARRPPGMINRVPEEQMTFKDLVSCTYQLARGMEYLASQKC
IHRDLAARNVLVTENNVMKIADFGLARVTNGRLPVKWMAPEALFDRVYTH
QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNEL
YMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT
3D structure
PDB5ugx Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
ChainB
Resolution2.349 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D626 A628 R630 N631 D644 R664
Catalytic site (residue number reindexed from 1) D154 A156 R158 N159 D172 R182
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP B G490 A491 F492 G493 A515 K517 A567 N571 L633 D644 G23 A24 F25 G26 A48 K50 A100 N104 L161 D172
BS02 MG B N631 D644 N159 D172
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5ugx, PDBe:5ugx, PDBj:5ugx
PDBsum5ugx
PubMed28166054
UniProtP21802|FGFR2_HUMAN Fibroblast growth factor receptor 2 (Gene Name=FGFR2)

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