Structure of PDB 5ugv Chain B

Receptor sequence
>5ugvB (length=244) Species: 419947 (Mycobacterium tuberculosis H37Ra) [Search protein sequence]
GMRVGVLGAKGKVGATMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEVV
IDFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTSV
LIAPNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTAK
LIAEARKGLPPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLFG
TEGETLTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEPLLD
3D structure
PDB5ugv Comparative structural and mechanistic studies of 4-hydroxy-tetrahydrodipicolinate reductases from Mycobacterium tuberculosis and Vibrio vulnificus.
ChainB
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.17.1.8: 4-hydroxy-tetrahydrodipicolinate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD B G7 G10 K11 V12 D33 A34 F52 T53 G75 T77 P103 G8 G11 K12 V13 D34 A35 F53 T54 G76 T78 P104
Gene Ontology
Molecular Function
GO:0008839 4-hydroxy-tetrahydrodipicolinate reductase
GO:0016491 oxidoreductase activity
GO:0016597 amino acid binding
GO:0016726 oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
GO:0016743 carboxyl- or carbamoyltransferase activity
GO:0050661 NADP binding
GO:0051287 NAD binding
GO:0070402 NADPH binding
GO:0070404 NADH binding
Biological Process
GO:0006520 amino acid metabolic process
GO:0009085 lysine biosynthetic process
GO:0009089 lysine biosynthetic process via diaminopimelate
GO:0019877 diaminopimelate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ugv, PDBe:5ugv, PDBj:5ugv
PDBsum5ugv
PubMed32980502
UniProtP9WP23|DAPB_MYCTU 4-hydroxy-tetrahydrodipicolinate reductase (Gene Name=dapB)

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