Structure of PDB 5ufi Chain B

Receptor sequence
>5ufiB (length=193) Species: 9606 (Homo sapiens) [Search protein sequence]
SLDRKKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWK
FRAATQCEFSKQEFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFY
QFTFNFAKNPGQKGLDLEMAIAYWNLVLNGRFKFLDLWNKFLLEHHKRSI
PKDTWNLLLDFSTMIADDMSNYDEEGAWPVLIDDFVEFARPQI
3D structure
PDB5ufi A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation.
ChainB
Resolution2.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8B1 B I86 F89 V102 Q114 C115 E116 F117 F164 M177 Y181 I28 F31 V44 Q56 C57 E58 F59 F106 M119 Y123 BindingDB: IC50=21nM
BS02 8B1 B I83 I86 P97 I25 I28 P39 BindingDB: IC50=21nM
External links
PDB RCSB:5ufi, PDBe:5ufi, PDBj:5ufi
PDBsum5ufi
PubMed29074978
UniProtQ96GG9|DCNL1_HUMAN DCN1-like protein 1 (Gene Name=DCUN1D1)

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