Structure of PDB 5u8c Chain B

Receptor sequence
>5u8cB (length=283) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGM
NVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEV
VYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRGTQVTGLSDKK
FQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTRFNQRGVEDALVS
LKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGS
PWKRQIDLALLQFVGDGEMEELETLWLTGICHN
3D structure
PDB5u8c Novel Mode of Antagonist Binding in NMDA Receptors Revealed by the Crystal Structure of the GluN1-GluN2A Ligand-Binding Domain Complexed to NVP-AAM077.
ChainB
Resolution1.598 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 84J B H88 S114 T116 R121 G172 S173 T174 Y214 D215 H85 S111 T113 R118 G169 S170 T171 Y211 D212 MOAD: Ki=29.58nM
PDBbind-CN: -logKd/Ki=7.53,Ki=29.58nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5u8c, PDBe:5u8c, PDBj:5u8c
PDBsum5u8c
PubMed28468946
UniProtQ00959|NMDE1_RAT Glutamate receptor ionotropic, NMDA 2A (Gene Name=Grin2a)

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