Structure of PDB 5u7g Chain B

Receptor sequence
>5u7gB (length=547) Species: 10090 (Mus musculus) [Search protein sequence]
GAMGSSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGI
PDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTS
RVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQNDTLDPEPFVDCK
ECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRL
GNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGE
MSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYL
DSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIF
HCHPPDQKIPKPKRLQEWYKKMLDKAFAERIINDYKDIFKQANEDRLTSA
KELPYFEGDFWPNVLEESIKESGKLYATMEKHKEVFFVIHLHQPPIVDPD
PLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRF
VYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHTHKMVKWGLGLD
3D structure
PDB5u7g Role of the CBP catalytic core in intramolecular SUMOylation and control of histone H3 acetylation.
ChainB
Resolution2.401 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H1292 C1295 H157 C160
BS02 ZN B C1284 C1287 C1309 C149 C152 C174
BS03 ZN B C1708 C1711 C1730 C1733 C504 C507 C526 C529
BS04 ZN B C1721 C1724 H1739 H1741 C517 C520 H535 H537
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:5u7g, PDBe:5u7g, PDBj:5u7g
PDBsum5u7g
PubMed28630323
UniProtP45481|CBP_MOUSE Histone lysine acetyltransferase CREBBP (Gene Name=Crebbp)

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