Structure of PDB 5u62 Chain B

Receptor sequence
>5u62B (length=354) Species: 9606 (Homo sapiens) [Search protein sequence]
YSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQ
GEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPIT
MQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIF
GGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD
YNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIV
CWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLAL
GNQVGKLYVWDLEVCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWR
WDRL
3D structure
PDB5u62 Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.
ChainB
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B W103 H104 S105 Y154 S159 P161 R201 L246 L315 G316 D317 L318 L353 F372 W373 Q374 R420 W24 H25 S26 Y75 S80 P82 R122 L167 L236 G237 D238 L239 L274 F293 W294 Q295 R334
BS02 7WD B F97 Y148 D310 Y365 R367 F18 Y69 D231 Y286 R288 MOAD: ic50=1.3uM
BindingDB: IC50=1300nM
External links
PDB RCSB:5u62, PDBe:5u62, PDBj:5u62
PDBsum5u62
PubMed27992714
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

[Back to BioLiP]