Structure of PDB 5u3r Chain B

Receptor sequence
>5u3rB (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
ADLKAFSKHIYNAYLKNFNMTKKKARSILTGAPFVIHDIETLWQAEKGLV
WLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQV
TLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIE
PKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILR
ALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSL
HPLLQEIYKDM
3D structure
PDB5u3r Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
ChainB
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B7G B K283 E435 I436 K438 K104 E256 I257 K259
BS02 B7G B L275 N276 V279 L96 N97 V100
BS03 7V1 B V245 C249 T252 T253 H287 V305 I328 K331 H413 L433 Y437 V66 C70 T73 T74 H108 V126 I149 K152 H234 L254 Y258 BindingDB: EC50=511.8nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:5u3r, PDBe:5u3r, PDBj:5u3r
PDBsum5u3r
PubMed28320959
UniProtQ03181|PPARD_HUMAN Peroxisome proliferator-activated receptor delta (Gene Name=PPARD)

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