Structure of PDB 5u3f Chain B

Receptor sequence
>5u3fB (length=328) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
YHTDHMVSIDYAEGRGWHNARVIPYGPIELDPSAIVLHYAQEVFEGLKAY
RWADGSIVSFRADANAARLRSSARRLAIPELPDAVFIESLRQLIAVDKAW
VPGAGGEEALYLRPFIFATEPGLGVRPATQYRYLLIASPAIAPVSVWVST
EYVRACPGGTGAAKFGGNYAASLLAQAEAAENGCDQVVWLDAVERRYIEE
MGGMNIFFVLGSGGSARLVTPELSGSLLPGITRDSLLQLAIDAGFAVEER
RIDIDEWQKKAAAGEITEVFACGTAAVITPVARVRHGASEFRIADGQPGE
VTMALRDTLTGIQRGTFADTHGWMARLG
3D structure
PDB5u3f Mechanism-Based Inhibition of the Mycobacterium tuberculosis Branched-Chain Aminotransferase by d- and l-Cycloserine.
ChainB
Resolution1.695 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K204
Catalytic site (residue number reindexed from 1) K164
Enzyme Commision number 2.6.1.42: branched-chain-amino-acid transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7TS B G79 R101 Y144 K204 Y209 E240 G243 M244 N245 L268 G270 I271 T272 G313 T314 G46 R68 Y111 K164 Y169 E200 G203 M204 N205 L228 G230 I231 T232 G273 T274
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004084 branched-chain-amino-acid transaminase activity
GO:0005515 protein binding
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0052654 L-leucine-2-oxoglutarate transaminase activity
GO:0052655 L-valine-2-oxoglutarate transaminase activity
GO:0052656 L-isoleucine-2-oxoglutarate transaminase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009081 branched-chain amino acid metabolic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0009098 L-leucine biosynthetic process
GO:0009099 L-valine biosynthetic process
GO:0018272 protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
GO:0071267 L-methionine salvage

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Molecular Function
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Biological Process
External links
PDB RCSB:5u3f, PDBe:5u3f, PDBj:5u3f
PDBsum5u3f
PubMed28272868
UniProtP9WQ75|ILVE_MYCTU Branched-chain-amino-acid aminotransferase (Gene Name=ilvE)

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