Structure of PDB 5u00 Chain B

Receptor sequence
>5u00B (length=339) Species: 9606 (Homo sapiens) [Search protein sequence]
MDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMN
FINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLEL
TNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVME
RHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIF
KDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIY
KEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDL
FPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL
3D structure
PDB5u00 Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders.
ChainB
Resolution1.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7OV B H656 L770 L809 Q812 I826 Y827 F830 M847 Q859 F862 H79 L193 L232 Q235 I249 Y250 F253 M270 Q282 F285 MOAD: ic50=0.002uM
BindingDB: IC50=2nM
BS02 ZN B H660 H696 D697 D808 H83 H119 D120 D231
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:5u00, PDBe:5u00, PDBj:5u00
PDBsum5u00
PubMed28165743
UniProtO00408|PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosphodiesterase (Gene Name=PDE2A)

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