Structure of PDB 5tx3 Chain B

Receptor sequence
>5tx3B (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]
SGSMKDYDELLKYYELHETIGKVKLACHILTGEMVAIKIMDKKTEIEALK
NLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVV
FRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDGSLAYAAPELIQ
GLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSP
SSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDD
DCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRL
3D structure
PDB5tx3 MELK is not necessary for the proliferation of basal-like breast cancer cells.
ChainB
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D132 K134 E136 N137 D150 S171
Catalytic site (residue number reindexed from 1) D120 K122 E124 N125 D138 S140
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7MY B V25 K40 L86 Y88 C89 G92 E93 I149 V23 K38 L74 Y76 C77 G80 E81 I137
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5tx3, PDBe:5tx3, PDBj:5tx3
PDBsum5tx3
PubMed28926338
UniProtQ14680|MELK_HUMAN Maternal embryonic leucine zipper kinase (Gene Name=MELK)

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