Structure of PDB 5tui Chain B

Receptor sequence

>5tuiB (length=370) Species: 77133 (uncultured bacterium)

HIKILVIGVGVAGPAVAYWLKRFGFSPVLIEKSAAVRKGGQALDIRGIAT
HIAKEMGIYDQICNMRTQIKCGRYVDVKGNVLHEEQGETFGFRQDDEVEI
LRGDLVEILMKAIADIPCEFKQSVIKIEQNEDSVTVTYKDGRVENYDLVI
AADGIHSATRGMVFSKNEYQLINLGSYVSAFTIPNYLGLDHMELLCESNH
KLVTLQSDSQADKAMAGFMFRSKDEQEQKHFLHASFQNFGWETQNILNRM
PESDDFYFDAITQIKMKSWTKGRIALIGDAAYCPSPLSGQGNNLAFVGAY
ILAGELKKADGDYIQAFTRYNELLHPFVEANQQFGVWVSESSKEIAEARS
NKILAMIKSVSNSINLPQYE

3D structure

• PDB: 5tui Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes.
• Chain: B
• Resolution: 1.75 Å

Enzymatic activity

• Enzyme Commision number: 1.14.13.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	I10 V12 G13 V14 A15 E34 K35 Q44 A45 L46 D47 R105 D156 Y267 G288 D289 P296 G299 G301 N302	I7 V9 G10 V11 A12 E31 K32 Q41 A42 L43 D44 R102 D153 Y257 G278 D279 P286 G289 G291 N292
BS02	CTC	B	D47 R49 G94 F95 L205 G220 F221 M222 P296 V348	D44 R46 G91 F92 L202 G217 F218 M219 P286 V338

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0016491 oxidoreductase activity
• GO:0071949 FAD binding

Biological Process

• GO:0046677 response to antibiotic

External links

• PDB: RCSB:5tui, PDBe:5tui, PDBj:5tui
• PDBsum: 5tui
• PubMed: 28481346
• UniProt: A0A059WYP6|TET50_UNKP Flavin-dependent monooxygenase (Gene Name=tet(50))