Structure of PDB 5tuf Chain B

Receptor sequence
>5tufB (length=371) Species: 77133 (uncultured bacterium) [Search protein sequence]
IKILVIGVGVAGPAVAYWLKRFGFSPVLIEKSAAVRKGGQALDIRGIATH
IAKEMGIYDQICNMRTQIKCGRYVDVKGNVLHEEQGETFGFRQDDEVEIL
RGDLVEILMKAIADIPCEFKQSVIKIEQNEDSVTVTYKDGRVENYDLVIA
ADGIHSATRGMVFSKNEYQLINLGSYVSAFTIPNYLGLDHMELLCESNHK
LVTLQSDSQADKAMAGFMFRSKRDEQEQKHFLHASFQNFGWETQNILNRM
PESDDFYFDAITQIKMKSWTKGRIALIGDAAYCPSPLSGQGNNLAFVGAY
ILAGELKKADGDYIQAFTRYNELLHPFVEANQQFGVWVSESFLLKIAEAR
SNKILAMIKSVSNSINLPQYE
3D structure
PDB5tuf Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes.
ChainB
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B I10 V14 A15 E34 K35 R40 G42 Q44 R105 A155 D156 G157 Y267 G288 D289 N302 I6 V10 A11 E30 K31 R36 G38 Q40 R101 A151 D152 G153 Y257 G278 D279 N292
BS02 TDC B Q44 V181 L205 T207 M222 P296 Q40 V177 L201 T203 M218 P286 MOAD: ic50=83.2uM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0071949 FAD binding
Biological Process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:5tuf, PDBe:5tuf, PDBj:5tuf
PDBsum5tuf
PubMed28481346
UniProtA0A059WYP6|TET50_UNKP Flavin-dependent monooxygenase (Gene Name=tet(50))

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