Structure of PDB 5tt8 Chain B

Receptor sequence
>5tt8B (length=221) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
TKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTADLQFKYA
ASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKT
RPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQNFKEVALDAF
LPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSP
NQRPVQPDYNTVIIKSSAETR
3D structure
PDB5tt8 Structure-Activity Relationship for Sulfonamide Inhibition of Helicobacter pylori alpha-Carbonic Anhydrase.
ChainB
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H85 H110 H112 E116 H129 T191
Catalytic site (residue number reindexed from 1) H62 H87 H89 E93 H106 T165
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H110 H112 H129 H87 H89 H106
BS02 D8W B N108 H110 H112 H129 V131 L190 T191 N85 H87 H89 H106 V108 L164 T165 MOAD: Ki=315nM
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5tt8, PDBe:5tt8, PDBj:5tt8
PDBsum5tt8
PubMed28002963
UniProtA0A0M3KL20

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