Structure of PDB 5tqu Chain B

Receptor sequence
>5tquB (length=506) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence]
GPGSMKVEKVFFVTSPIYYVNAAPHIGHVYSTLITDVIGRYHRVKGERVF
ALTGTDEHGQKVAEAAKQKQVSPYDFTTAVAGEFKKCFEQMDYSIDYFIR
TTNEQHKAVVKELWTKLEQKGDIYLGRYEGWYSISVTWVSEENYMFRLSA
FRERLLEWYHANPGCIVPEFRRREVIRAVEKGLPDLSVSRARATLHNWAI
PVPGNPDHCVYVWLDALTNYLTGSRLRVDESGKEVSLVDDFNELERFPAD
VHVIGKDILKFHAIYWPAFLLSAGLPLPKKIVAHGWWTKDRKKISKSLGN
VFDPVEKAEEFGYDALKYFLLRESGFSDDGDYSDKNMIARLNGELADTLG
NLVMRCTSAKINVNGEWPSPAAYTEEDESLIQLIKDLPGTADHYYLIPDI
QKAIIAVFDVLRAINAYVTDMAPWKLVKTDPERLRTVLYITLEGVRVTTL
LLSPILPRKSVVIFDMLGVPEVHRKGIENFEFGAVPPGTRLGPAVEGEVL
FSKRST
3D structure
PDB5tqu From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis.
ChainB
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H256 H259 S364 K554 K557
Catalytic site (residue number reindexed from 1) H25 H28 S133 K293 K296
Enzyme Commision number 6.1.1.10: methionine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I53 B I248 Y250 D287 H289 G290 Y472 V473 W474 Y481 F522 I17 Y19 D56 H58 G59 Y211 V212 W213 Y220 F261 PDBbind-CN: -logKd/Ki=7.60,IC50<25nM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5tqu, PDBe:5tqu, PDBj:5tqu
PDBsum5tqu
PubMed28110521
UniProtQ38C91

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