Structure of PDB 5to3 Chain B

Receptor sequence
>5to3B (length=367) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETKGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSAGAGCDRDGKYGFYTHVFRLKKWIQKVIDQ
FGGGSEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFC
NQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNL
PGTFECICGARHIGTDC
3D structure
PDB5to3 Rational Design of Protein C Activators.
ChainB
Resolution2.34 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H58 D114 E217 G218 D219 S220 G221
Catalytic site (residue number reindexed from 1) H43 D99 E196 G197 D198 S199 G200
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0G6 B H58 Y62 W65 L111 D214 A215 S220 S241 A242 G243 H43 Y47 W50 L96 D193 A194 S199 S220 A221 G222
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:5to3, PDBe:5to3, PDBj:5to3
PDBsum5to3
PubMed28294177
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2);
P07204|TRBM_HUMAN Thrombomodulin (Gene Name=THBD)

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