Structure of PDB 5tmw Chain B

Receptor sequence

>5tmwB (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSEYDPFSEASMMGLLTNLADRELVHM
INWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPN
LLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSG
VYTFLTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLL
ILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL

3D structure

PDB

5tmw Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.

Chain

Resolution

2.286 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	I358 L372 Q375 V376 L379 E380 L539 E542	I51 L65 Q68 V69 L72 E73 L230 E233
BS02	7FP	B	L346 T347 E353 L387 F404 V418 E419 M421 I424 H524 L525	L39 T40 E46 L80 F97 V111 E112 M114 I117 H215 L216

External links

PDB	RCSB:5tmw, PDBe:5tmw, PDBj:5tmw
PDBsum	5tmw
PubMed	28042045
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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