Structure of PDB 5tmv Chain B

Receptor sequence

>5tmvB (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]

NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRE
LVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLL
FAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIIL
LNSGVYTFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQ
LLLILSHIRHMSNKGMEHLYSMKCVPLSDLLLEMLDAHR

3D structure

PDB

5tmv Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.

Chain

Resolution

2.38 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	I358 K362 L372 H373 Q375 V376 L379 D538 L539 E542	I55 K59 L69 H70 Q72 V73 L76 D229 L230 E233
BS02	7FO	B	M343 L346 T347 E353 L387 L391 F404 E419 G420 M421 I424 H524 L525 M528	M40 L43 T44 E50 L84 L88 F101 E116 G117 M118 I121 H218 L219 M222

External links

PDB	RCSB:5tmv, PDBe:5tmv, PDBj:5tmv
PDBsum	5tmv
PubMed	28042045
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

[Back to BioLiP]