Structure of PDB 5tmm Chain B

Receptor sequence
>5tmmB (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYPFSEASMMGLLTNLADRELVHMI
NWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNL
LLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGV
YTKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSN
KGMEHLYSMKSDLLLEMLDAHR
3D structure
PDB5tmm Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 V376 E542 M543 I50 K54 L64 V68 E216 M217
BS02 7M4 B M343 L346 T347 E353 L387 F404 E419 G420 M421 I424 H524 L525 M528 M35 L38 T39 E45 L79 F96 E111 G112 M113 I116 H205 L206 M209
External links
PDB RCSB:5tmm, PDBe:5tmm, PDBj:5tmm
PDBsum5tmm
PubMed28042045
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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