Structure of PDB 5tm8 Chain B

Receptor sequence
>5tm8B (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
NSLALSLTADQMVSALLDAEPPILYSEYPFSEASMMGLLTNLADRELVHM
INWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPN
LLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSG
VYTFKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHM
SNKGMEHLYSMKVVPLSDLLLEMLDAHR
3D structure
PDB5tm8 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
ChainB
Resolution1.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 V376 E380 L539 E542 I51 K55 L65 V69 E73 L219 E222
BS02 7K6 B A350 E353 L387 M388 F404 E419 G420 M421 I424 H524 L536 A43 E46 L80 M81 F97 E112 G113 M114 I117 H207 L216
External links
PDB RCSB:5tm8, PDBe:5tm8, PDBj:5tm8
PDBsum5tm8
PubMed28042045
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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