Structure of PDB 5tm7 Chain B

Receptor sequence
>5tm7B (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRL
AQLLLILSHIRHMSNKGMEHLYSMKCKLSDLLLEMLDAHR
3D structure
PDB5tm7 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 V376 L379 E380 D538 E542 I54 K58 L68 V72 L75 E76 D230 E234
BS02 7JY B M343 T347 E353 L387 M388 F404 G420 M421 I424 H524 L525 M528 K529 L540 M39 T43 E49 L83 M84 F100 G116 M117 I120 H220 L221 M224 K225 L232
External links
PDB RCSB:5tm7, PDBe:5tm7, PDBj:5tm7
PDBsum5tm7
PubMed28042045
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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