Structure of PDB 5tlx Chain B

Receptor sequence
>5tlxB (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQ
LLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB5tlx Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
ChainB
Resolution2.103 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 L372 V376 E380 D538 L539 E542 I54 L68 V72 E76 D232 L233 E236
BS02 7G5 B A350 L387 M388 L391 M421 H524 L525 A46 L83 M84 L87 M117 H218 L219
BS03 7EH B A350 E353 L387 L391 M421 A46 E49 L83 L87 M117
BS04 7G5 B A350 E353 L387 M421 L525 L540 A46 E49 L83 M117 L219 L234
External links
PDB RCSB:5tlx, PDBe:5tlx, PDBj:5tlx
PDBsum5tlx
PubMed28042045
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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