Structure of PDB 5tlo Chain B

Receptor sequence
>5tloB (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTPFSEASMMGLLTNLADRELV
HMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFA
PNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN
SGVYTKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRH
MSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB5tlo Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
ChainB
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 V376 E380 D538 E542 I53 K57 L67 V71 E75 D222 E226
BS02 7EE B M343 E353 L387 R394 F404 V418 E419 M421 G521 H524 M38 E48 L82 R89 F99 V113 E114 M116 G205 H208 BindingDB: EC50=10nM
External links
PDB RCSB:5tlo, PDBe:5tlo, PDBj:5tlo
PDBsum5tlo
PubMed28042045
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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