Structure of PDB 5th6 Chain B

Receptor sequence
>5th6B (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
RQLAEEYLYRYGYTRVAGPALLLLQKQLSLPETGELDTLKAMRTPRCGVP
DLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVT
PLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDA
HFDDDELWSGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLH
KDDVNGIRHLY
3D structure
PDB5th6 Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9.
ChainB
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H401 E402 H405 H411
Catalytic site (residue number reindexed from 1) H169 E170 H173 H179
Enzyme Commision number 3.4.24.35: gelatinase B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C99 H401 H405 H411 C47 H169 H173 H179
BS02 ZN B H175 D177 H190 H203 H123 D125 H138 H151
BS03 CA B D165 G197 Q199 D201 D113 G145 Q147 D149
BS04 CA B D182 G183 D185 L187 D205 E208 D130 G131 D133 L135 D153 E156
BS05 CA B D131 D206 E208 D79 D154 E156
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5th6, PDBe:5th6, PDBj:5th6
PDBsum5th6
PubMed28235803
UniProtP14780|MMP9_HUMAN Matrix metalloproteinase-9 (Gene Name=MMP9)

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