Structure of PDB 5tc3 Chain B

Receptor sequence

>5tc3B (length=489) Species: 284811 (Eremothecium gossypii ATCC 10895)

TYRDAATALEHLATYAEKDGLSVEQLMDSKTRGGLTYNDFLVLPGKIDFP
SSEVVLSSRLTKKITLNAPFVSSPMDTVTEADMAIHMALLGGIGIIHHNC
TAEEQAEMVRRVKKYENGFINAPVVVGPDATVADVRRMKNEFGFAGFPVT
DDGKPTGKLQGIITSRDIQFVEDETLLVSEIMTKDVITGKQGINLEEANQ
ILKNTKKGKLPIVDEAGCLVSMLSRTDLMKNQSYPLASKSADTKQLLCGA
AIGTIDADRQRLAMLVEAGLDVVVLDSSQGNSVFQINMIKWIKETFPDLQ
VIAGNVVTREQAASLIHAGADGLRIGMGSGSICITQEVMACGRPQGTAVY
NVTQFANQFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTESPG
EYFRDRLKTYRGSIDAMAQGVTGSVIDKGSIKKYIPYLYNGLQHSCQDIG
VRSLVEFREKVDSGSVRFEFRTPSAQLEGGVHNLHSLFD

3D structure

• PDB: 5tc3 A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases.
• Chain: B
• Resolution: 2.462 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.205: IMP dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	5GP	B	S74 R325 G331 S332 C334 T336 D367 G390 G391 Y414 G418	S73 R324 G330 S331 C333 T335 D366 G389 G390 Y410 G412
BS02	ATP	B	T165 R167 D168 T184 V187 I188 G209 K210	T164 R166 D167 T183 V186 I187 G208 K209
BS03	GDP	B	K115 N118 I121 V125 F145 G147 K210 M223 S225 T227 D228 K231	K114 N117 I120 V124 F144 G146 K209 M222 S224 T226 D227 K230
BS04	GDP	B	E117 N118 G119 N200 L229 N232 K240 K245	E116 N117 G118 N199 L228 N231 K239 K244

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003824 catalytic activity
• GO:0003938 IMP dehydrogenase activity
• GO:0005524 ATP binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006164 purine nucleotide biosynthetic process
• GO:0006177 GMP biosynthetic process
• GO:0006183 GTP biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5tc3, PDBe:5tc3, PDBj:5tc3
• PDBsum: 5tc3
• PubMed: 28572600
• UniProt: Q756Z6