Structure of PDB 5t9j Chain B

Receptor sequence
>5t9jB (length=391) Species: 9606 (Homo sapiens) [Search protein sequence]
GVNDLWQILEPVKQHIPLRNLGGKTIAVNLSLWVCEAQTVKKMMGSVMKP
HLRNLFFRISYLTQMDVKLVFVMEGEPPKLRYGSSGKSWSQKTGRSHFKS
VLRECLHMLECLGIPWVQAAGEAEAMCAYLNAGGHVDGCLTNDGDTFLYG
AQTVYRNFTMNTKDPHVDCYTMSSIKSKLGLDRDALVGLAILLGCDYLPK
GVPGVGKEQALKLIQILKGQSLLQRFNRWNQLNEVENNIKKKACCCEGFP
FHEVIQEFLLNKDKLVKVIRYQRPDLLLFQRFTLEKMEWPNHYACEKLLV
LLTHYDMIERKLGSRNSNQLQPIRIVKTRIRNGVHCFEIEWEKPEHYAME
DKQHGEFALLTIEEESLFEAAYPEIVAVYQKQKLEIKGKKQ
3D structure
PDB5t9j Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage.
ChainB
Resolution3.00013 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B K43 R54 N55 F58 R59 M172 Y370 K374 K42 R53 N54 F57 R58 M160 Y293 K297
BS02 dna B M44 R54 R406 I407 N409 M43 R53 R329 I330 N332
BS03 MG B E75 E134 E74 E122
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity

View graph for
Molecular Function
External links
PDB RCSB:5t9j, PDBe:5t9j, PDBj:5t9j
PDBsum5t9j
PubMed26682650
UniProtQ17RS7|GEN_HUMAN Flap endonuclease GEN homolog 1 (Gene Name=GEN1)

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