Structure of PDB 5t6g Chain B

Receptor sequence
>5t6gB (length=164) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence]
TLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSIAIHQAG
EFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLAVRMGA
IASMRIQGRLVHGQSGMLLTGMDLGTIPGDCGAPYVHKRGNDWVVCGVHA
AATKSGNTVVCAVQ
3D structure
PDB5t6g Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors.
ChainB
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N40 B H30 E54 I109 Q110 T134 I135 C139 H157 A158 A159 A160 H27 E51 I106 Q107 T126 I127 C131 H149 A150 A151 A152
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5t6g, PDBe:5t6g, PDBj:5t6g
PDBsum5t6g
PubMed27914364
UniProtQ83883|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)

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