Structure of PDB 5t5c Chain B

Receptor sequence
>5t5cB (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
VLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMGDADRK
HCKFKPDPNIPPTFSAFNEDYVGSGWSRGAMAPAGNNKFSSKAMAETFYL
SNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTRGDGKK
IVSYQVIGEDNVAVPSHLYKVILARRSSVSTEPLALGAFVVPNEAIGFQP
QLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQEFTLY
LSTRKIEGARSVLRLEKIMENLKNAEIEPDDYFMSRYEKKLEELKA
3D structure
PDB5t5c A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease.
ChainB
Resolution1.851 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C112 A140 N162 N171 E179
Catalytic site (residue number reindexed from 1) C52 A80 N102 N111 E119
Enzyme Commision number 3.1.30.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B R109 S137 R138 G145 K148 F168 N171 S172 N176 R49 S77 R78 G85 K88 F108 N111 S112 N116 PDBbind-CN: Kd=4.13uM
BS02 dna B K113 S172 K315 R320 R324 K53 S112 K255 R260 R264 PDBbind-CN: Kd=4.13uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5t5c, PDBe:5t5c, PDBj:5t5c
PDBsum5t5c
PubMed28466855
UniProtQ9Y2C4|EXOG_HUMAN Nuclease EXOG, mitochondrial (Gene Name=EXOG)

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