Structure of PDB 5sy7 Chain B

Receptor sequence
>5sy7B (length=276) Species: 10090 (Mus musculus) [Search protein sequence]
RKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYL
KMRDFANQGDIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYL
GLSQVELTGSSVFDYVHPGDHVEMAEQLGMLERSFFIRMKSTLGYKVIHI
TGRLRMGLVVVAHALPHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGK
RCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATI
AKNIIWVNYLLSNPEYKDTPMDIAQL
3D structure
PDB5sy7 NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.
ChainB
Resolution4.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B K62 R70 K4 R12 PDBbind-CN: Kd=17.5nM
BS02 dna B K60 R64 R71 N75 K97 K2 R6 R13 N17 K39 PDBbind-CN: Kd=17.5nM
Gene Ontology
Molecular Function
GO:0046983 protein dimerization activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5sy7, PDBe:5sy7, PDBj:5sy7
PDBsum5sy7
PubMed27782878
UniProtQ9QZQ0|NPAS3_MOUSE Neuronal PAS domain-containing protein 3 (Gene Name=Npas3)

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