Structure of PDB 5sxw Chain B

Receptor sequence
>5sxwB (length=714) Species: 320372 (Burkholderia pseudomallei 1710b) [Search protein sequence]
NGTSNRDWWPNQLDLSILHRHSSLSDPMGKDFNYAQAFEKLDLAAVKRDL
HALMTTSQDWWPADFGHYGGLFIRMAWHSAGTYRTADGRGGAGEGQQRFA
PLNSWPDNANLDKARRLLWPIKQKYGRAISWADLLILTGNVALESMGFKT
FGFAGGRADTWEPADVYWGSEKIWLELSGGPNSRYSGDRQLENPLAAVQM
GLIYVNPEGPDGNPDPVAAARDIRDTFARMAMNDEETVALIAGGHTFGKT
HGAGPASNVGAEPEAAGIEAQGLGWKSAYRTGKGADAITSGLEVTWTTTP
TQWSHNFFENLFGYEWELTKSPAGAHQWVAKGADAVIPDAFDPSKKHRPT
MLTTDLSLRFDPAYEKISRRFHENPEQFADAFARAWFKLTHRDMGPRARY
LGPEVPAEVLLWQDPIPAVDHPLIDAADAAELKAKVLASGLTVSQLVSTA
WAAASTFRGSDKRGGANGARIRLAPQKDWEANQPEQLAAVLETLEAIRTA
FNGAQRGGKQVSLADLIVLAGCAGVEQAAKNAGHAVTVPFAPGRADASQE
QTDVESMAVLEPVADGFRNYLKGKYRVPAEVLLVDKAQLLTLSAPEMTVL
LGGLRVLGANVGQSRHGVFTAREQALTNDFFVNLLDMGTEWKPTAADADV
FEGRDRATGELKWTGTRVDLVFGSHSQLRALAEVYGSADAQEKFVRDFVA
VWNKVMNLDRFDLA
3D structure
PDB5sxw Isonicotinic acid hydrazide conversion to Isonicotinyl-NAD by catalase-peroxidases.
ChainB
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R108 H112 H279 W330 D389
Catalytic site (residue number reindexed from 1) R74 H78 H245 W296 D355
Enzyme Commision number 1.11.1.21: catalase peroxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B G104 L105 X111 V239 P241 L274 I275 G278 H279 G282 K283 T284 H285 T323 S324 W420 G70 L71 X77 V205 P207 L240 I241 G244 H245 G248 K249 T250 H251 T289 S290 W386
BS02 OXY B R108 H112 R74 H78
Gene Ontology
Molecular Function
GO:0004096 catalase activity
GO:0004601 peroxidase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0006979 response to oxidative stress
GO:0042744 hydrogen peroxide catabolic process
GO:0070301 cellular response to hydrogen peroxide
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5sxw, PDBe:5sxw, PDBj:5sxw
PDBsum5sxw
PubMed20554537
UniProtQ3JNW6|KATG_BURP1 Catalase-peroxidase (Gene Name=katG)

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