Structure of PDB 5sxk Chain B

Receptor sequence
>5sxkB (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
LQDAEWYWGSREEVNEKLRDTADGTFLVRDTKMHGDYTLTLRKGGNNKLI
KIDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKYPVSQVVKEDN
IEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETI
KIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDS
RRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQ
KKLNEWL
3D structure
PDB5sxk Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design.
ChainB
Resolution3.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 71K B N377 N378 N46 N47 PDBbind-CN: -logKd/Ki=4.70,IC50=20uM
External links
PDB RCSB:5sxk, PDBe:5sxk, PDBj:5sxk
PDBsum5sxk
PubMed28129991
UniProtP27986|P85A_HUMAN Phosphatidylinositol 3-kinase regulatory subunit alpha (Gene Name=PIK3R1)

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