Structure of PDB 5s7n Chain B

Receptor sequence
>5s7nB (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
DITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVM
LRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCL
RIVLSIASGLAHLHIEIFGKPAIAHRDLKSKNILVKKNGQCCIADLGLAV
MHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGL
VLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPN
RWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID
3D structure
PDB5s7n XChem group deposition
ChainB
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LU8 B V214 A233 K235 L281 T283 Y285 H286 G289 D293 L343 A353 V8 A27 K29 L75 T77 Y79 H80 G83 D87 L134 A144 BindingDB: IC50=29nM
BS02 2AI B L306 L495 T496 I498 D499 L100 L286 T287 I289 D290
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:5s7n, PDBe:5s7n, PDBj:5s7n
PDBsum5s7n
PubMed
UniProtQ04771|ACVR1_HUMAN Activin receptor type-1 (Gene Name=ACVR1)

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