Structure of PDB 5s7j Chain B

Receptor sequence
>5s7jB (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
RDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTV
MLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSC
LRIVLSIASGLAHLHIEIFGKPAIAHRDLKSKNILVKKNGQCCIADLGLA
VMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFG
LVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIP
NRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID
3D structure
PDB5s7j XChem group deposition
ChainB
Resolution1.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LU8 B V214 A233 K235 L281 T283 Y285 H286 G289 D293 L343 A353 V9 A28 K30 L76 T78 Y80 H81 G84 D88 L135 A145 BindingDB: IC50=29nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5s7j, PDBe:5s7j, PDBj:5s7j
PDBsum5s7j
PubMed
UniProtQ04771|ACVR1_HUMAN Activin receptor type-1 (Gene Name=ACVR1)

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