Structure of PDB 5s7i Chain B

Receptor sequence

>5s7iB (length=294) Species: 9606 (Homo sapiens)

ARDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNT
VMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVS
CLRIVLSIASGLAHLHIEIFGQGKPAIAHRDLKSKNILVKKNGQCCIADL
GLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIW
AFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRP
NIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID

3D structure

• PDB: 5s7i XChem group deposition
• Chain: B
• Resolution: 1.3 Å

Enzymatic activity

• Enzyme Commision number: 2.7.11.30: receptor protein serine/threonine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	LU8	B	V214 A233 K235 L281 T283 Y285 H286 G289 D293 L343 A353	V10 A29 K31 L77 T79 Y81 H82 G85 D89 L138 A148	BindingDB: IC50=29nM
BS02	HV2	B	E389 F441	E184 F236
BS03	HV2	B	K216 G220	K12 G16
BS04	HV2	B	H361 N366 Q367 L368 D394 C395 F396	H156 N161 Q162 L163 D189 C190 F191
BS05	HV2	B	Q453 R454 N456	Q248 R249 N251
BS06	HV2	B	Q296 D426	Q92 D221
BS07	HV2	B	T299 L300 D301 S304	T95 L96 D97 S100

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004675 transmembrane receptor protein serine/threonine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation
• GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5s7i, PDBe:5s7i, PDBj:5s7i
• PDBsum: 5s7i
• UniProt: Q04771|ACVR1_HUMAN Activin receptor type-1 (Gene Name=ACVR1)